報告題目：影像遺傳在神經學中的挑戰和機會
報告人：Jingyu Liu
講座時間：6月21日下午14:30
講座地點：西北工業大學正禾賓館西三樓會議室
邀請人：謝松云 教授
承辦學院：電子信息學院
聯系人：謝松云
聯系電話：029-88431206
報告簡介：
Challenges and opportunities in Imaging Genetics in Psychiatry
Since the approach of imaging genetics was first applied to psychiatry in early 2000, prominent advances have been documented along with excitement and frustration. Using schizophrenia as an example, GWASs leveraging unprecedented large samples have produced much reliable genetic risk variants for the disorder, while ENIGMA projects present resourceful genetic links with brain structure. Yet combining these two, no clear overlapping genetic architecture was observed, at least so far. Different research groups have different takes for the current status, and we believe it promotes sophisticated analytic methods, refined phenotypic angles, and in-depth biological model along genetics to brain while conducting imaging genetic analyses. We have demonstrated shared genetic risk for schizophrenia and brain structure in 6p22.1 through mutlivariate association analyses, and verified such genetic risks’ regulation role on DNA methylation and gene expression. And the risk alleles for schizophrenia derived from post-mortem brain tissues are consistent with the risk alleles for gray matter reduction of patients derived from in-vivo imagining. In parallel, we also investigated genetic regulated epigenetics, specifically DNA methylation Quantitative Trait Loci (mQTL), and methylation association with brain structure. We showed that epigenetics, incorporating both genetic risks and environmental factors, carry much stronger connections with brain than SNPs, and many of epigenetic variation regulated by genetics have cross tissue (brain, blood and saliva) correspondence, which opens up a way for future imaging-genetic analyses for psychiatric disorders.
報告人簡介：
Jingyu Liu received the Master degree in electrical engineering from the Northern Jiaotong University, Beijing, China, and the Ph.D. degree in electrical engineering from the University of New Mexico (UNM), USA, in 2004. She is currently Associate Professor in Translational Neuroscience at Mind Research Network, Albuquerque, NM, and Research Professor in the Department of Electrical and Computer Engineering, UNM. Her research interests include design of multimodal data mining algorithms applied to biomedical data, such as brain imaging and signals, genetic and epigenetic data, clinical and neuropsychological assessments, etc. She has been focusing on the interdisciplinary research field to bridge engineering with neuroscience, and (epi)genetics, and has published more than 60 scientific journal papers, and led NIH supported projects for investigation of genetic influences on brain anomalies related to schizophrenia, ADHD, addiction, and Huntington’s disease.
