報告題目：Opportunities for Porous Silicon in Nanomedicine
報告人：Nicolas Voelcker教授
講座時間：2018年11月13日上午9：00
講座地點：友誼校區老圖書館401
邀請人：李林 教授
承辦單位：柔性電子研究院
聯系人：王添
聯系電話：18269103286
報告簡介：
This talk will explore the application of nanostructured silicon including porous silicon and silicon nanowires in drug and gene delivery, optical and electrochemical biosensors and in regenerative medicine. These elemental silicon-based materials have high surface area of up to several hundreds of square meters per gram, facilitating loading of considerable amounts of bioactives. Second, pore size can be tailored over a wide range, spanning from the nano- to the microscale. Being able to 'dial in' a certain pore size allows for facile optimisation of topographical cues for attachment, guidance, proliferation and differentiation of target cells. At the same time, the rate of diffusive release of drugs can be tuned by adjusting the pore size. Third, the materials are biocompatible and biodegradable, with the nanostructured elemental silicon undergoing oxidative hydrolysis in aqueous medium at a rate that is easily tunable by means of the surface chemistry from hours to months. A diverse range of surface chemistries is available for this material, some of which are amenable to surface patterning, formation of surface-bound gradients and formation of silicon-polymer hybrid materials. Finally, thin films, membranes and particles of porous silicon display interferometric reflectance and photonic effects, which are responsive to binding of target biomolecules. This talk will first introduce nanostructured silicon material properties and fabrication and characterisation aspects, including describing strategies for nano- and microscale patterning and gradient formation. This will be followed by an overview of the work using porous silicon nanostructured films as optical and electrochemical transducers. Drug delivery applications for targeted cancer therapy, immunotherapy and the therapy of ocular diseases will be highlighted, and the use of nanostructured silicon in chronic wound diagnostics and theranostics will be discussed. Finally, the talk will provide an example of the use of porous carrier material for ocular cell therapy.
報告人簡介：
Nicolas Voelcker教授于1999年獲得博士學位（RWTH Aachen），并在Scrippts Research Institute從事博士后工作3年，師從M.R. Ghadiri教授。2001年Nico加入Flinders University，并在2008年提拔為教授以及理學院副院長。2012年Nico加入南澳大學（University of South Australia），并于同年成為Mawson Institute院長。2017年Nico加入莫納什（Monash）大學藥學院（藥劑藥理學世界排名第二），并與同年成為Melbourne Centre for Nanofabrication (墨爾本納米中心，MCN)院長以及澳大利亞聯邦科學與工業研究組織(CSIRO)科研領頭人。他同時還擔任莫納什大學工程與材料學院教授，以及Leibniz Institute for New Materials（德國）客座教授，University Rovira I Virgili（西班牙）客座教授。他還是澳大利亞皇家化學學會，和英國皇家化學學會理事。
Nico在生物納米材料和生物表面材料上作出了許多貢獻。在多孔硅納米材料（Porous Silicon Nanoparticles, pSiNPs）的生物應用上Nico作出了開創性研究（超過100篇高質量文章），并享有極高的國際聲譽（多孔硅材料世界前五）。他還設計了多孔硅傳感器，利用材料特質從而提高了信號強度。Nico還在納米針以及納米線上發表了多篇高質量文章。迄今為止Nico共發表了350篇學術論文，10本書以及25項專利，總引數超過7500次，年引用次數超過1100次/年，h-index 49，其中包括國際學術期刊Nature Communication, Nature Nanotechnology, Advanced Material, Advanced Functional Material以及Biometerial等。Nico已經獲得了十余項獎項，包括南澳年度科學家（2015）。
